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Journal Highlight: Detection of trace amounts of citrinin in dried orange peel by using an optimized extraction method coupled with ultra‐performance liquid chromatography–tandem mass spectrometry

Date: Apr 23, 2018

Author: separationsNOW

A fast and sensitive method involving ultra‐performance liquid chromatography–tandem mass spectrometry has been introduced to detect the mycotoxin citrinin in dried orange peel.

Read More thumbnail image: Journal Highlight Detection of trace amounts of citrinin in dried orange peel by using an optimized extraction method coupled with ultraperformance liquid chromatographytandem mass spectrometry

Liquorice lessens alarming alkaloid levels

Date: Apr 9, 2018

Author: Ryan De Vooght-Johnson

The seeds of the tree Strychnos nux-vomica (‘Semen Strychni’), are used in traditional Chinese medicine, despite containing the poisonous alkaloids strychnine and brucine. Scientists from the Central South University (Changsha, China) used LC-MS to examine alkaloids from ‘Semen Strychni’ and compounds from liquorice, since it has been claimed that liquorice can reduce the toxicity of these seeds.

Read More thumbnail image: Liquorice lessens alarming alkaloid levels

Easy assay by LC is suitable for ADCs

Date: Apr 1, 2018

Author: Ryan De Vooght-Johnson

Antibody–drug conjugates (ADCs) are increasingly used in cancer treatment, but their analytical quantification can be difficult. Researchers from South Korea have developed a single-platform method for assaying such conjugates using LC-MS, applying it to the commercial drug brentuximab vedotin (Adcetris).

Read More thumbnail image: Easy assay by LC is suitable for ADCs

Journal Highlight: Enantioselective ultra high performance liquid and supercritical fluid chromatography: The race to the shortest chromatogram

Date: Mar 26, 2018

Author: separationsNOW

An overview of recent achievements in the field of ultra‐high‐resolution chromatography on columns packed with chiral stationary phases has been given, with an emphasis on very recent studies on ultrafast chiral separations.

Read More thumbnail image: Journal Highlight Enantioselective ultra high performance liquid and supercritical fluid chromatography The race to the shortest chromatogram

Heavy atoms show the way for dsRNA assay

Date: Mar 15, 2018

Author: Ryan De Vooght-Johnson

Double-stranded RNA (dsRNA) has several potential uses, but production methods tend to give mixtures with other types of RNA, rendering assays difficult. Researchers from Sheffield University and Syngenta’s Jealott’s Hill site (Berkshire) used isotopically labelled dsRNA in conjunction with LC-MS to determine the amount of dsRNA in RNA mixtures from modified E. coli.

Read More thumbnail image: Heavy atoms show the way for dsRNA assay

Poisoning response is quick, as LC-MS does the trick

Date: Mar 1, 2018

Author: Ryan De Vooght-Johnson

Cases of acute poisoning by pharmaceuticals, often due to attempted suicide or children taking someone else’s medication, require rapid determination of the substances involved and their levels in the bloodstream. Researchers from the University of Saarland in Germany have developed a rapid UHPLC-MS/MS method to determine the levels of a wide number of pharmaceutical compounds in blood samples.

Read More thumbnail image: Poisoning response is quick as LC-MS does the trick

Journal Highlight: Transfer rates of aflatoxins from herbal medicines to decoctions determined by an optimized HPLC with fluorescence detection method

Date: Feb 19, 2018

Author: separationsNOW

The transfer rates of aflatoxins from five fungi-contaminated raw herbal medicines to their decoctions have been measured by HPLC with fluorescence detection after postcolumn photochemical derivatization.

Read More thumbnail image: Journal Highlight Transfer rates of aflatoxins from herbal medicines to decoctions determined by an optimized HPLC with fluorescence detection method

Super isomer separation succeeds with cellulose

Date: Feb 15, 2018

Author: Ryan De Vooght-Johnson

Pyrethroids are widely used insecticides, which are usually sold as mixtures of enantiomers. These isomers have different activities and environmental effects. Scientists from China's Southwest University in Chongqing have developed new methods to separate the enantiomeric isomers of two pyrethroids, bifenthrin and lambda-cyhalothrin, using reversed-phase HPLC.

Read More thumbnail image: Super isomer separation succeeds with cellulose

Design and degradation in drug determination

Date: Feb 1, 2018

Author: Ryan De Vooght-Johnson

There is a need for new analytical methods for the anticancer drug sorafenib, which are suitable both for the compound itself and its degradation products. Researchers from Panjab University in India used an analytical quality by design approach (AQbD), including a face-centred cubic experimental design, to devise a new HPLC method for sorafenib and its degradation products.

Read More thumbnail image: Design and degradation in drug determination

Journal Highlight: Chromatographic methods in HIV medicine: Application to therapeutic drug monitoring

Date: Jan 22, 2018

Author: separationsNOW

This review summarises the analytical methods relevant to therapeutic monitoring of HIV drugs, including HPLC-UV and LC-MS/MS, while highlighting respective challenges.

Read More thumbnail image: Journal Highlight Chromatographic methods in HIV medicine Application to therapeutic drug monitoring
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