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Journal Highlight: Comparative analysis of marketed factor VIII products: Recombinant products are not alike vis‐a‐vis soluble protein aggregates and subvisible particles

Date: Jul 23, 2018

Author: separationsNOW

The critical quality parameters of recombinant factor VIII products such as the concentrations of soluble protein aggregates and subvisible particles have been compared by HPLC-SEC and flow cytometry under intended use and use‐relevant stress conditions.

Read More thumbnail image: Journal Highlight Comparative analysis of marketed factor VIII products Recombinant products are not alike visavis soluble protein aggregates and subvisible particles

Monoclonal mixtures measured in plasma

Date: Jul 20, 2018

Author: Ryan De Vooght-Johnson

The use of animals in pharmaceutical pharmacokinetic studies needs to be minimised for both ethical and financial reasons. Scientists from Chungnam National University, Daejeon, South Korea, investigated the use of multiple dosing (known as cassette dosing) for following the pharmacokinetics of four monoclonal antibodies by means of LC-MS.

Read More thumbnail image: Monoclonal mixtures measured in plasma

Journal Highlight: Microbial and metabolic multi‐omic correlations in systemic sclerosis patients

Date: Jun 25, 2018

Author: separationsNOW

The fecal microbiota and plasma metabolomes of patients with systemic sclerosis have been characterised, showing that a reduced model of nine bacteria can differentiate patients from healthy controls.

Read More thumbnail image: Journal Highlight Microbial and metabolic multiomic correlations in systemic sclerosis patients

Cannabis compounds in cords captured by UHPLC

Date: Jun 18, 2018

Author: Ryan De Vooght-Johnson

The use of cannabis during pregnancy can lead to adverse effects on babies so objective methods are needed to determine whether cannabis has been taken. Scientists from the City University of New York and the University of Santiago de Compostela, Spain, devised a new UHPLC-MS/MS method for detecting the main active ingredient of cannabis (THC) and its metabolites in umbilical cords.

Read More thumbnail image: Cannabis compounds in cords captured by UHPLC

Journal Highlight: Updating chromatographic predictions by accounting ageing for single and tandem columns

Date: Jun 11, 2018

Author: separationsNOW

Models for predicting chromatographic behaviour on single and coupled columns which have aged have been adapted to correct the time and peak profiles.

Read More thumbnail image: Journal Highlight Updating chromatographic predictions by accounting ageing for single and tandem columns

Chiral LC solves honey mystery

Date: May 25, 2018

Author: Ryan De Vooght-Johnson

Traces of the antibiotic chloramphenicol, which is banned in food-producing animals, were detected by LC-MS in honey being exported from the Ukraine, but an ELISA test proved negative. Scientists from the SCIVP (a government institute in Lviv, Ukraine), R-Biopharm AG (Darmstadt, Germany) and Wageningen University and Research Centre (Netherlands) used chiral LC to investigate the discrepancy.

Read More thumbnail image: Chiral LC solves honey mystery

Journal Highlight: Rapid oligonucleotide drug impurity determination by direct spectral comparison of ion pair‐reversed phase HPLC ESI MS data

Date: May 21, 2018

Author: separationsNOW

A novel approach for the rapid determination of changes in the impurity profile of oligonucleotide therapeutics has been developed based on quantitative ion pair HPLC/MS and the introduction of a combined ranking index.

Read More thumbnail image: Journal Highlight Rapid oligonucleotide drug impurity determination by direct spectral comparison of ion pairreversed phase HPLC ESI MS data

CCD Optimisation Gives Good Flavonoid Separation

Date: May 18, 2018

Author: Ryan De Vooght-Johnson

Flavonoids are naturally occurring compounds found in many types of fruit and vegetables, but the analysis of these closely related substances presents a challenge. Scientists from the University of Kragujevac and the University of Belgrade (both in Serbia) optimised the conditions for the HPLC separation of five flavonoids in fruit juices with the aid of a central composite design (CCD).

Read More thumbnail image: CCD Optimisation Gives Good Flavonoid Separation

Fatty acids from foamy films found by TOF and TWIMS

Date: May 4, 2018

Author: Ryan De Vooght-Johnson

The sea surface microlayer (SML), roughly the top millimetre of the ocean, contains relatively high concentrations of organic compounds, including fatty acids. Scientists from the University of Stockholm used a combination of UHPLC, time-of-flight mass spectrometry (TOF-MS) and travelling-wave ion mobility spectrometry (TWIMS) to separate and identify a complex mixture of fatty acids from the Arctic Ocean SML.

Read More thumbnail image: Fatty acids from foamy films found by TOF and TWIMS

The force of Orbitrap can thwart doping from the dark side of sport

Date: May 2, 2018

Author: Ryan De Vooght-Johnson

The use of anabolic steroids by athletes for doping purposes remains a serious problem, but existing analytical methods tend to give poor detection of some steroids, particularly novel ‘designer steroids’, which are often not found in databases. Researchers from the Federal University of Rio de Janeiro and Thermo Fisher (Austin, Texas) devised a new method using GC and an Orbitrap mass spectrometer to detect both known and novel anabolic steroids, along with other doping compounds.

Read More thumbnail image: The force of Orbitrap can thwart doping from the dark side of sport
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