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Journal Highlight: Quantification of hydrolyzed peptides and proteins by amino acid fluorescence

Date: Aug 20, 2018

Author: separationsNOW

HPLC using ion‐pairing coupled to fluorescence detection has been used to measure tyrosine, phenylalanine, and tryptophan from hydrolysed peptides without requiring prior derivatization, which will be useful in drug discovery.

Read More thumbnail image: Journal Highlight Quantification of hydrolyzed peptides and proteins by amino acid fluorescence

More alcohol is seen to make your LC green

Date: Aug 20, 2018

Author: Ryan De Vooght-Johnson

HPLC traditionally uses environmentally harmful solvents, such as acetonitrile, although less harmful alternatives often work just as well. Scientists from the Ahram Canadian University (near Cairo) and Ain Shams University (Cairo) used experimental design to optimise two HPLC systems, both using ethanol and buffer solution, for the analysis of cardiovascular drugs, examining the results using two different green evaluation tools.

Read More thumbnail image: More alcohol is seen to make your LC green

DBS and LC-MS crack cocaine analysis

Date: Aug 9, 2018

Author: Ryan De Vooght-Johnson

The accurate analysis of cocaine and its metabolites in blood samples is important for both health professionals and law enforcement agencies. Scientists from the University of Pavia, Italy, devised a new method of analysing dried blood spots (DBSs) containing cocaine or its metabolites by LC-MS/MS, applying it to post-mortem blood samples.

Read More thumbnail image: DBS and LC-MS crack cocaine analysis

Journal Highlight: Comparative analysis of marketed factor VIII products: Recombinant products are not alike vis‐a‐vis soluble protein aggregates and subvisible particles

Date: Jul 23, 2018

Author: separationsNOW

The critical quality parameters of recombinant factor VIII products such as the concentrations of soluble protein aggregates and subvisible particles have been compared by HPLC-SEC and flow cytometry under intended use and use‐relevant stress conditions.

Read More thumbnail image: Journal Highlight Comparative analysis of marketed factor VIII products Recombinant products are not alike visavis soluble protein aggregates and subvisible particles

Monoclonal mixtures measured in plasma

Date: Jul 20, 2018

Author: Ryan De Vooght-Johnson

The use of animals in pharmaceutical pharmacokinetic studies needs to be minimised for both ethical and financial reasons. Scientists from Chungnam National University, Daejeon, South Korea, investigated the use of multiple dosing (known as cassette dosing) for following the pharmacokinetics of four monoclonal antibodies by means of LC-MS.

Read More thumbnail image: Monoclonal mixtures measured in plasma

Journal Highlight: Microbial and metabolic multi‐omic correlations in systemic sclerosis patients

Date: Jun 25, 2018

Author: separationsNOW

The fecal microbiota and plasma metabolomes of patients with systemic sclerosis have been characterised, showing that a reduced model of nine bacteria can differentiate patients from healthy controls.

Read More thumbnail image: Journal Highlight Microbial and metabolic multiomic correlations in systemic sclerosis patients

Cannabis compounds in cords captured by UHPLC

Date: Jun 18, 2018

Author: Ryan De Vooght-Johnson

The use of cannabis during pregnancy can lead to adverse effects on babies so objective methods are needed to determine whether cannabis has been taken. Scientists from the City University of New York and the University of Santiago de Compostela, Spain, devised a new UHPLC-MS/MS method for detecting the main active ingredient of cannabis (THC) and its metabolites in umbilical cords.

Read More thumbnail image: Cannabis compounds in cords captured by UHPLC

Journal Highlight: Updating chromatographic predictions by accounting ageing for single and tandem columns

Date: Jun 11, 2018

Author: separationsNOW

Models for predicting chromatographic behaviour on single and coupled columns which have aged have been adapted to correct the time and peak profiles.

Read More thumbnail image: Journal Highlight Updating chromatographic predictions by accounting ageing for single and tandem columns

Chiral LC solves honey mystery

Date: May 25, 2018

Author: Ryan De Vooght-Johnson

Traces of the antibiotic chloramphenicol, which is banned in food-producing animals, were detected by LC-MS in honey being exported from the Ukraine, but an ELISA test proved negative. Scientists from the SCIVP (a government institute in Lviv, Ukraine), R-Biopharm AG (Darmstadt, Germany) and Wageningen University and Research Centre (Netherlands) used chiral LC to investigate the discrepancy.

Read More thumbnail image: Chiral LC solves honey mystery

Journal Highlight: Rapid oligonucleotide drug impurity determination by direct spectral comparison of ion pair‐reversed phase HPLC ESI MS data

Date: May 21, 2018

Author: separationsNOW

A novel approach for the rapid determination of changes in the impurity profile of oligonucleotide therapeutics has been developed based on quantitative ion pair HPLC/MS and the introduction of a combined ranking index.

Read More thumbnail image: Journal Highlight Rapid oligonucleotide drug impurity determination by direct spectral comparison of ion pairreversed phase HPLC ESI MS data
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