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Nano-LC determination shows up strange glycosylation

Date: Feb 14, 2019

Author: Ryan De Vooght-Johnson

Idiopathic REM sleep behaviour disorder is a condition considered to be a precursor to serious neurodegenerative diseases, such as Parkinson’s disease, so there is interest in finding biomarkers for this disorder. A multi-centre team of scientists, from Texas Tech University (Lubbock), the American University of Beirut and the Oasi Research Institute (Troina, Italy) used nano-LC/MS techniques to examine the differences in glycosylation patterns between patients with the disorder and unaffected...

Read More thumbnail image: Nano-LC determination shows up strange glycosylation

Extraction optimised with care to measure parabens in hair

Date: Jan 29, 2019

Author: Ryan De Vooght-Johnson

Parabens are commonly used preservatives found in cosmetics, personal cleaning products and pharmaceuticals, but human exposure to them needs to be monitored as they have oestrogenic properties (i.e. mimic female sex hormones). Researchers from the Korea Research Institute of Chemical Technology in Daejeon, South Korea, devised a new method to quantify five parabens in human hair using online extraction, UHPLC and MS/MS.

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Journal Highlight: Detection of plant protein in adulterated milk using nontargeted nano‐high‐performance liquid chromatography–tandem mass spectroscopy combined with principal component analysis

Date: Jan 29, 2019

Author: separationsNOW

Plant protein in adulterated in milk has been detected by nano-HPLC/MS/MS in conjunction with proteomics, using principal components to discriminate it from authentic milk.

Read More thumbnail image: Journal Highlight Detection of plant protein in adulterated milk using nontargeted nanohighperformance liquid chromatographytandem mass spectroscopy combined with principal component analysis

Fragment filters find flavonoids and saponins

Date: Jan 28, 2019

Author: Ryan De Vooght-Johnson

Liquorice and the medicinal dried root known as Bupleuri radix are used to treat liver conditions in China, but the complex mixtures of compounds present in these remedies are difficult to analyse. Scientists from the Tianjin University of Traditional Chinese Medicine, China, used mass spectral data from the literature to find particular characteristic fragments and neutral losses that aided the classification and identification of the triterpenoids present.

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Make-up solvent selection for ESI detection

Date: Jan 16, 2019

Author: Ryan De Vooght-Johnson

The solvent output from HPLC is sometimes split, e.g. when radioactivity detection and mass spectrometry are both required; one of the output streams is often then diluted with extra solvent (make-up solvent). Scientists from the University of Tartu (Estonia) and Janssen (Beerse, Belgium) examined the optimum make-up solvent for ESI mass spectrometry on a range of pharmaceutical compounds, while also looking at the effect of splitting.

Read More thumbnail image: Make-up solvent selection for ESI detection

Deceitful dodgy drinkers detected by LC-MS/MS

Date: Jan 10, 2019

Author: Ryan De Vooght-Johnson

One of the challenges facing those treating alcoholism is unreported drinking by patients who are supposed to be abstaining, which necessitates the use of analytical methods to detect alcohol metabolites. Scientists from the University of Antwerp and Stuivenberg Psychiatric Hospital (Antwerp) developed a novel method of detecting the ethanol metabolite ethyl sulphate in hair using LC-MS/MS.

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Coloured crocus compounds caught by CPC

Date: Jan 7, 2019

Author: Ryan De Vooght-Johnson

The red/yellow spice saffron contains a variety of compounds, some of which are of potential pharmaceutical interest. Researchers from the University of Athens and the Goulandris Natural History Museum (Athens) used centrifugal partition chromatography (CPC) to separate some of the main compounds in saffron, optimising the conditions to give a preparative method for the isolation of trans-crocin-4. 

Read More thumbnail image: Coloured crocus compounds caught by CPC

Journal Highlight: A collaborative work on quantitative HPLC methods for the routine determination of atranol and chloroatranol in moss extracts

Date: Dec 17, 2018

Author: separationsNOW

Two analytical methods based on RP-HPLC-DAD and LC/MS-SIM for routine quantification of the suspected skin allergens atranol and chloroatranol in moss have been developed in round-robin tests.

Read More thumbnail image: Journal Highlight A collaborative work on quantitative HPLC methods for the routine determination of atranol and chloroatranol in moss extracts

Effective amine derivatisation made possible by automation

Date: Dec 14, 2018

Author: Ryan De Vooght-Johnson

A number of amines tend to be formed in food when it spoils, and analysis is required to detect these potentially harmful and unpleasant compounds. Researchers from Deakin University and Kemin Nutriscience (both Geelong, Australia) used dansyl derivatisation and HPLC to measure seven amines in pet food.

Read More thumbnail image: Effective amine derivatisation made possible by automation

QTRAP keeps consumables clear of cannabinoids

Date: Nov 29, 2018

Author: Ryan De Vooght-Johnson

Products derived from hemp are increasingly used in both animal feed and items intended for human consumption, but this trend has led to a need to monitor the levels of cannabinoids in such products. Scientists from the Institute of Experimental Veterinary Preventive Medicine for Southern Italy in Naples have developed a novel LC-MS/MS system for measuring nine cannabinoids in foodstuffs.

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