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QTRAP keeps consumables clear of cannabinoids

Date: Nov 29, 2018

Author: Ryan De Vooght-Johnson

Products derived from hemp are increasingly used in both animal feed and items intended for human consumption, but this trend has led to a need to monitor the levels of cannabinoids in such products. Scientists from the Institute of Experimental Veterinary Preventive Medicine for Southern Italy in Naples have developed a novel LC-MS/MS system for measuring nine cannabinoids in foodstuffs.

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Journal Highlight: Assessment of altered cholesterol homeostasis by xenobiotics using ultra‐high performance liquid chromatography–tandem mass spectrometry

Date: Nov 19, 2018

Author: separationsNOW

UHPLC‐MS/MS methods have been developed for the quantitative assessment of altered post‐squalene cholesterol biosynthesis and subsequent oxysterol formation in various sample types.

Read More thumbnail image: Journal Highlight Assessment of altered cholesterol homeostasis by xenobiotics using ultrahigh performance liquid chromatographytandem mass spectrometry

Separation solved by cyclodextrin in solvent

Date: Nov 8, 2018

Author: Ryan De Vooght-Johnson

It is important to be able to determine the enantiomeric purity of chiral drugs, but existing chiral HPLC methods are expensive and use large amounts of solvent. Researchers from Alexandria University used a Box-Behnken experimental design to optimise an HPTLC method for separating the enantiomers of three β-blocker drug compounds.

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Journal Highlight: Investigation of low molecular weight peptides (<1kDa) in chicken meat and their contribution to meat flavor formation

Date: Oct 22, 2018

Author: separationsNOW

44 Low-molecular-weight peptides have been identified in stored chicken meat by LC/MS and their role in the formation of flavour compounds has been assessed in model systems.

Read More thumbnail image: Journal Highlight Investigation of low molecular weight peptides 1kDa in chicken meat and their contribution to meat flavor formation

The walrus and the chromatographer: LC-MS/MS of steroids in bone

Date: Oct 1, 2018

Author: Ryan De Vooght-Johnson

Examination of the steroid hormone levels in animals from past generations can give useful information on stress and reproduction. Researchers from the University of Alaska Fairbanks and Purdue University (West Lafayette, Indiana) used LC-MS/MS to detect steroid hormones in bones from walruses that had died recently and also those from ancient specimens.

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Processed purée pongs prevented by LC-MS

Date: Sep 27, 2018

Author: Ryan De Vooght-Johnson

Tomato products can be spoiled, giving rise to unpleasant tastes, by various species of Alicyclobacillus bacteria. Researchers from The Experimental Station for the Food Processing Industry in Parma, Italy, used LC-MS to identify specific compounds linked to the growth of these bacteria in tomato purée.

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Journal Highlight: A rapid method to determine nine natural cannabinoids in beverages and food derived from Cannabis sativa by liquid chromatography coupled to tandem mass spectrometry on a QTRAP 4000

Date: Sep 21, 2018

Author: separationsNOW

An LC/MS/MS method has been developed for measuring nine phytocannabinoids in food and beverages derived from hemp seeds, flour and oil.

Read More thumbnail image: Journal Highlight A rapid method to determine nine natural cannabinoids in beverages and food derived from Cannabis sativa by liquid chromatography coupled to tandem mass spectrometry on a QTRAP 4000

Mutated genes are plain to see using dHPLC

Date: Sep 12, 2018

Author: Ryan De Vooght-Johnson

Denaturing HPLC (dHPLC) uses ion-pair reversed-phase HPLC to separate homoduplex and heteroduplex DNA molecules, but typically produces large amounts of data. Scientists from the Institute of Technology and Higher Education (Monterrey, Mexico) and the ‘ISSSTESON’ institute (Hermosillo, Mexico) used dHPLC in combination with principal component analysis (PCA) and box plots to detect DNA point mutations associated with cancer.

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Paracetamol pulverises proteins via para-benzoquinone metabolite

Date: Aug 30, 2018

Author: Ryan De Vooght-Johnson

Paracetamol overdose can cause severe liver damage due to the binding of the reactive metabolite NAPQI to liver proteins. Scientists from two Canadian institutions, the University of Quebec at Montreal and the University of Alberta (Edmonton), used LC-MS/MS to quantify the adduct formed from NAPQI and human serum albumen (HSA), this being a useful biomarker for the amount of NAPQI bound to liver proteins.

Read More thumbnail image: Paracetamol pulverises proteins via para-benzoquinone metabolite

Journal Highlight: Quantification of hydrolyzed peptides and proteins by amino acid fluorescence

Date: Aug 20, 2018

Author: separationsNOW

HPLC using ion‐pairing coupled to fluorescence detection has been used to measure tyrosine, phenylalanine, and tryptophan from hydrolysed peptides without requiring prior derivatization, which will be useful in drug discovery.

Read More thumbnail image: Journal Highlight Quantification of hydrolyzed peptides and proteins by amino acid fluorescence
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