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Journal Highlight: Rapid oligonucleotide drug impurity determination by direct spectral comparison of ion pair‐reversed phase HPLC ESI MS data

Date: May 21, 2018

Author: separationsNOW

A novel approach for the rapid determination of changes in the impurity profile of oligonucleotide therapeutics has been developed based on quantitative ion pair HPLC/MS and the introduction of a combined ranking index.

Read More thumbnail image: Journal Highlight Rapid oligonucleotide drug impurity determination by direct spectral comparison of ion pairreversed phase HPLC ESI MS data

CCD Optimisation Gives Good Flavonoid Separation

Date: May 18, 2018

Author: Ryan De Vooght-Johnson

Flavonoids are naturally occurring compounds found in many types of fruit and vegetables, but the analysis of these closely related substances presents a challenge. Scientists from the University of Kragujevac and the University of Belgrade (both in Serbia) optimised the conditions for the HPLC separation of five flavonoids in fruit juices with the aid of a central composite design (CCD).

Read More thumbnail image: CCD Optimisation Gives Good Flavonoid Separation

Fatty acids from foamy films found by TOF and TWIMS

Date: May 4, 2018

Author: Ryan De Vooght-Johnson

The sea surface microlayer (SML), roughly the top millimetre of the ocean, contains relatively high concentrations of organic compounds, including fatty acids. Scientists from the University of Stockholm used a combination of UHPLC, time-of-flight mass spectrometry (TOF-MS) and travelling-wave ion mobility spectrometry (TWIMS) to separate and identify a complex mixture of fatty acids from the Arctic Ocean SML.

Read More thumbnail image: Fatty acids from foamy films found by TOF and TWIMS

The force of Orbitrap can thwart doping from the dark side of sport

Date: May 2, 2018

Author: Ryan De Vooght-Johnson

The use of anabolic steroids by athletes for doping purposes remains a serious problem, but existing analytical methods tend to give poor detection of some steroids, particularly novel ‘designer steroids’, which are often not found in databases. Researchers from the Federal University of Rio de Janeiro and Thermo Fisher (Austin, Texas) devised a new method using GC and an Orbitrap mass spectrometer to detect both known and novel anabolic steroids, along with other doping compounds.

Read More thumbnail image: The force of Orbitrap can thwart doping from the dark side of sport

Journal Highlight: Detection of trace amounts of citrinin in dried orange peel by using an optimized extraction method coupled with ultra‐performance liquid chromatography–tandem mass spectrometry

Date: Apr 23, 2018

Author: separationsNOW

A fast and sensitive method involving ultra‐performance liquid chromatography–tandem mass spectrometry has been introduced to detect the mycotoxin citrinin in dried orange peel.

Read More thumbnail image: Journal Highlight Detection of trace amounts of citrinin in dried orange peel by using an optimized extraction method coupled with ultraperformance liquid chromatographytandem mass spectrometry

Liquorice lessens alarming alkaloid levels

Date: Apr 9, 2018

Author: Ryan De Vooght-Johnson

The seeds of the tree Strychnos nux-vomica (‘Semen Strychni’), are used in traditional Chinese medicine, despite containing the poisonous alkaloids strychnine and brucine. Scientists from the Central South University (Changsha, China) used LC-MS to examine alkaloids from ‘Semen Strychni’ and compounds from liquorice, since it has been claimed that liquorice can reduce the toxicity of these seeds.

Read More thumbnail image: Liquorice lessens alarming alkaloid levels

Easy assay by LC is suitable for ADCs

Date: Apr 1, 2018

Author: Ryan De Vooght-Johnson

Antibody–drug conjugates (ADCs) are increasingly used in cancer treatment, but their analytical quantification can be difficult. Researchers from South Korea have developed a single-platform method for assaying such conjugates using LC-MS, applying it to the commercial drug brentuximab vedotin (Adcetris).

Read More thumbnail image: Easy assay by LC is suitable for ADCs

Journal Highlight: Enantioselective ultra high performance liquid and supercritical fluid chromatography: The race to the shortest chromatogram

Date: Mar 26, 2018

Author: separationsNOW

An overview of recent achievements in the field of ultra‐high‐resolution chromatography on columns packed with chiral stationary phases has been given, with an emphasis on very recent studies on ultrafast chiral separations.

Read More thumbnail image: Journal Highlight Enantioselective ultra high performance liquid and supercritical fluid chromatography The race to the shortest chromatogram

Heavy atoms show the way for dsRNA assay

Date: Mar 15, 2018

Author: Ryan De Vooght-Johnson

Double-stranded RNA (dsRNA) has several potential uses, but production methods tend to give mixtures with other types of RNA, rendering assays difficult. Researchers from Sheffield University and Syngenta’s Jealott’s Hill site (Berkshire) used isotopically labelled dsRNA in conjunction with LC-MS to determine the amount of dsRNA in RNA mixtures from modified E. coli.

Read More thumbnail image: Heavy atoms show the way for dsRNA assay

Poisoning response is quick, as LC-MS does the trick

Date: Mar 1, 2018

Author: Ryan De Vooght-Johnson

Cases of acute poisoning by pharmaceuticals, often due to attempted suicide or children taking someone else’s medication, require rapid determination of the substances involved and their levels in the bloodstream. Researchers from the University of Saarland in Germany have developed a rapid UHPLC-MS/MS method to determine the levels of a wide number of pharmaceutical compounds in blood samples.

Read More thumbnail image: Poisoning response is quick as LC-MS does the trick
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