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Characterization of Impurities and Degradants Using Mass Spectrometry

Date: May 10, 2011

Author: Birendra Pramanik, Mike S. Lee, Guodong Chen

The book highlights the current practices and future trends in structural characterization of impurities and degradants. It begins with an overview of mass spectrometry techniques as related to the analysis of impurities and degradants, followed by studies involving characterization of process related impurities (including potential genotoxic impurities), and excipient related impurities in formulated products.  Both general practitioners in pharmaceutical research and specialists in analytical...

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Mass Spectrometry in Drug Metabolism and Disposition: Basic Principles and Applications

Date: Apr 26, 2011

Author: Mike S. Lee, Mingshe Zhu

This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within...

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Protein Purification: Principles, High Resolution Methods, and Applications, 3rd Edition

Date: Apr 8, 2011

Author: Jan-Christer Janson

This thoroughly revised and updated third edition provides an overview of the principles and methodology of the most frequently used biochemical separation techniques for proteins used today. Balancing theory, procedures, and applications, it offers professionals and students in biochemistry, organic chemistry, and analytical chemistry quick access to a wide range of important techniques, including: Gel filtration and ion exchange chromatography Affinity and covalent chromatography  Reversed phase...

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Analysis of Chemical Warfare Degradation Products

Date: Mar 15, 2011

Author: Karolin K. Kroening, Renee N. Easter, Douglas D. Richardson, Stuart A. Willison, Joseph A. Caruso

This book describes nerve agents and vesicants, their decomposition and their degradation products' chemistry as well as their toxicity including a list of detection techniques of nerve agents and their degradation products. This book will present their history, toxicity, comparison between different sample preparation methods, separation techniques, and detection methods all together in a short, easy to read book, tied together by a single group doing the writing and the editing to assure smooth...

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Encyclopedia of Analytical Chemistry: Applications, Theory and Instrumentation, Supplementary Volumes S1 - S3

Date: Feb 18, 2011

Author: Robert A. Meyers

The new 3-Volume Supplementary Set for Encyclopedia of Analytical Chemistry contains 95 new articles (published online in Encyclopedia of Analytical Chemistry (EAC) from 2008 – 2010), covering subjects which have achieved particular prominence and distinction since the print publication of EAC in 2000. The new 3 Volume Set includes advances in applications and theory ranging from mass spectrometry, atomic, infrared, Raman and X-ray spectroscopy, to nuclear magnetic resonance and...

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Light Scattering, Size Exclusion Chromatography and Asymmetric Flow Field Flow Fractionation: Powerful Tools for the Characterization of Polymers, Proteins and Nanoparticles

Date: Feb 15, 2011

Author: Stepan Podzimek

A comprehensive, practical approach to three powerful methods of polymer analysis and characterization This book serves as a complete compendium of three important methods widely used for the characterization of synthetic and natural polymers—light scattering, size exclusion chromatography (SEC), and asymmetric flow field flow fractionation (A4F). Featuring numerous up-to-date examples of experimental results obtained by light scattering, SEC, and A4F measurements, Light Scattering, Size Exclusion...

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Genotoxic Impurities: Strategies for Identification and Control

Date: Feb 15, 2011

Author: Andrew Teasdale

This book examines genotoxic impurities and their impact on the pharmaceutical industry. Specific sections examine this from both a toxicological and analytical perspective. Within these sections, the book defines appropriate strategies to both assess and ultimately control genotoxic impurities, thus aiding the reader to develop effective control measures. An opening section covers the development of guidelines and the threshold of toxicological concern (TTC) and is followed by a section on...

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Handbook of Alcoholic Beverages: Technical, Analytical and Nutritional Aspects, 2 Volume Set

Date: Jan 28, 2011

Author: Alan J. Buglass

A comprehensive two- volume set that describes the science and technology involved in the production and analysis of alcoholic beverages. At the heart of all alcoholic beverages is the process of fermentation, particularly alcoholic fermentation, whereby sugars are converted to ethanol and many other minor products. The Handbook of Alcoholic Beverages tracks the major fermentation process, and the major chemical, physical and technical processes that accompany the production of the world’s most...

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Analytical Methods for Therapeutic Drug Monitoring and Toxicology

Date: Jan 28, 2011

Author: Q. Alan Xu, Timothy L. Madden

This book is a compilation of summarized analytical methods designed to serve the needs of pharmacologists, toxicologists, and other allied health professionals involved the development, use, or monitoring of pharmaceuticals. The summaries are structured monographs on 511 different drug entities detailing 964 different analytical methods, providing the reader with a thorough description of method validation. These analytical methods include not only high performance liquid chromatography (HPLC), but also...

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Regulated Bioanalytical Laboratories: Technical and Regulatory Aspects from Global Perspectives

Date: Jan 21, 2011

Author: Michael Zhou

This book provides useful information for bioanalytical / analytical scientists, analysts, quality assurance managers, and all personnel in bioanalytical laboratories through all aspects of bioanalytical technical and regulatory perspectives within bioanalytical operations and processes. Readers learn how to develop and implement strategies for routine, non-routine, and standard bioanalytical methods and on the entire equipment hardware and software qualification process. The book also gives guidelines on...

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