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Protein and Peptide Mass Spectrometry in Drug Discovery

Date: Dec 23, 2011

Author: Michael L. Gross, Guodong Chen, Birendra Pramanik

The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discovery An instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to large proteins, mass spectrometry (MS) has become one of the most widely used techniques for studying proteins and peptides over the last decade. Bringing together the work of experts in academia and industry, Protein and Peptide Mass Spectrometry in Drug Discovery...

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Introduction to Pharmaceutical Chemical Analysis

Date: Dec 16, 2011

Author: Steen Hansen, Stig Pedersen-Bjergaard, Knut Rasmussen

This textbook is the first to present a systematic introduction to chemical analysis of pharmaceutical raw materials, finished pharmaceutical products, and of drugs in biological fluids, which are carried out in pharmaceutical laboratories worldwide. In addition, this textbook teaches the fundamentals of all the major analytical techniques used in the pharmaceutical laboratory, and teaches the international pharmacopoeias and guidelines of importance for the field. It is primarily intended for the...

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Mathematical Methods for Physical and Analytical Chemistry

Date: Nov 15, 2011

Author: David Z. Goodson

Mathematical Methods for Physical and Analytical Chemistry presents mathematical and statistical methods to students of chemistry at the intermediate, post-calculus level. The content includes a review of general calculus; a review of numerical techniques often omitted from calculus courses, such as cubic splines and Newton’s method; a detailed treatment of statistical methods for experimental data analysis; complex numbers; extrapolation; linear algebra; and differential equations. With...

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Amino Acids, Peptides and Proteins in Organic Chemistry, Volume 5, Analysis and Function of Amino Acids and Peptides

Date: Oct 19, 2011

Author: Andrew B. Hughes

This is the last of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series.  Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international "who's who" in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric...

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Comprehensive Chromatography in Combination with Mass Spectrometry

Date: Aug 26, 2011

Author: Luigi Mondello

This book provides a detailed description of various multidimensional chromatographic separation techniques. The editor first provides an introduction to the area and then dives right into the various complex separation techniques. While still not used routinely comprehensive chromatography techniques will help acquaint the readers with the fundamentals and possible benefits of multi-dimensional separations coupled with mass spectrometry. The topics include a wide range of material that will appease all...

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Mass Spectral and GC Data of Drugs, Poisons, Pesticides, Pollutants and Their Metabolites, 4th Edition

Date: Aug 24, 2011

Author: Hans H. Maurer, Karl Pfleger, Armin A. Weber

The world's most comprehensive reference for forensic toxicologists is keeping pace with recent developments in clinical toxicology in its new release: Another 800 new spectra have been added to this gold standard, including novel designer drugs and a broad range of AIDS therapeutics, for a total of 8,650 clinically relevant substances, including 5,200 metabolites. The print edition contains a comprehensive listing of all compounds in order of molecular mass, showing a reference mass spectrum as well as...

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Pharmaceutical Anti-Counterfeiting: Combating the Real Danger from Fake Drugs

Date: Aug 12, 2011

Author: Mark Davison

This book overviews and integrates the business and technical issues that pharmaceutical companies need to know in order to combat the major global problem of counterfeit medicines. In addition to discussion of the problems, the author Davison addresses analytical techniques scientists use to detect counterfeits and presents some possible solutions to the threat of counterfeit medical products. Coverage moves from basic overview of the problem, costs / risks to consumers (toxic products, mistrust of drug...

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Protein NMR Spectroscopy: Practical Techniques and Applications

Date: Jul 22, 2011

Author: Gordon Roberts, Lu-Yun Lian

Nuclear Magnetic Resonance (NMR) spectroscopy, a physical phenomenon based upon the magnetic properties of certain atomic nuclei, has found a wide range of applications in life sciences over recent decades. The dramatic advances in NMR techniques have led to corresponding advances in the ability of NMR to study structure, dynamics and interactions of biological macromolecules in solution under close to physiological conditions. This volume focuses on the use of NMR to study proteins. NMR can be used to...

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Illicit Drugs in the Environment: Occurrence, Analysis, and Fate using Mass Spectrometry

Date: May 13, 2011

Author: Sara Castiglioni, Ettore Zuccato, Roberto Fanelli

Illicit drugs are an emerging class of environmental contaminants and mass spectrometry is the technique of choice for their analysis. This landmark reference discusses the analytical techniques used to detect illicit drugs in wastewater and surface water, details how to estimate the levels of contaminants in the environment, and explores the behavior, fate, and toxic effects of this new class of contaminants, now a ubiquitous presence in wastewater and surface water. The book details how an estimate of...

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Platelet Proteomics: Principles, Analysis, and Applications

Date: May 10, 2011

Author: Ángel García-Alonso, Yotis Senis

The purpose of the book is to introduce platelets, and their functional role in thrombotic and cardiovascular disease, justifying the relevance of platelet proteomics research. Focus then shifts to the recent developments on mass spectrometry (MS)-based proteomics.  This chapter shows potential applications for platelet proteomics not yet carried out.  It includes examples of post-translational modifications (PTMs) analysis in platelets. The second part of the book focuses on the main research...

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