Easy and Rapid Analysis of Antibody Drug Conjugates and Highly Hydrophobic Proteins

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Webinar

  • Date: Jun 26, 2014 - 15:00 - 16:00 (local time)
  • Presenter: Susan Darling, April Xu, Scott MackProteinSimple
  • Categories: HPLC
thumbnail image: Easy and Rapid Analysis of Antibody Drug Conjugates and Highly Hydrophobic Proteins

Easy and Rapid Analysis of Antibody Drug Conjugates
and Highly Hydrophobic Proteins

Broadcast on June 26, 2014
This webinar is now available on-demand.
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Automated methods for charge heterogeneity detection such as imaged capillary isoelectric focusing (icIEF) have been widely adopted by the biopharma industry. These techniques provide rapid high resolution charge variant separation with easy method development and minimal start up time. Imaged cIEF also offers the ability to analyze complex antibody drug conjugates (ADC) and highly hydrophobic peptides and proteins.

In this webinar Susan Darling will provide an overview of the iCE technology followed by April Xu, Ph.D, Senior Scientist at Pfizer who will present the application of cIEF to enhance process understanding and product characterization for a lysine chemistry-based ADC as well as for monitoring the drug load distribution in final drug product. Scott Mack will review new strategies for analyzing highly hydrophobic proteins such as high density lipoproteins and how to reduce aggregation and hydrophobic interactions during analysis.

What You Will Learn About:

  • Rapid charge heterogeneity analysis of biopharmaceuticals
  • Ability to analyze complex antibody drug conjugates and highly hydrophobic peptides and proteins
  • Application of cIEF to enhance process understanding and product characterization for lysine chemistry

Who Should Attend:

  • QC Laboratory Managers
  • R&D Scientists
  • Scientists performing Charge Heterogeneity Analysis
  • Process Development Scientists/Managers
  • Scientist using Capillary Electrophoresis or HPLC
  • Scientists using Gel Isoelectric Focusing
  • CMO/CRO Scientist and Managers
  • Formulation Chemists/Scientists
  • Protein Analytical Development Scientists
  • Routine testing groups 

Your Presenters

Susan Darling

Marketing Manager
iCE and MFI
ProteinSimple

April Xu, PhD

Senior Principal Scientist
Pfizer

Scott Mack

Senior Scientist
ProteinSimple


Register now >>>

In association with:
  
                                 Pittcon 2014                             Current Protocols

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