Singapore’s BTI joins Waters’ innovation program

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  • Published: Feb 28, 2017
  • Source: Waters Corporation
  • Suppliers: Waters Corporation
  • Channels: HPLC / Ion Chromatography / Detectors / Laboratory Informatics / Proteomics & Genomics / Sample Preparation / Electrophoresis / Gas Chromatography / Chemometrics & Informatics / MRI Spectroscopy / Base Peak / NMR Knowledge Base / Infrared Spectroscopy / Raman / X-ray Spectrometry / UV/Vis Spectroscopy / Atomic / Proteomics

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Waters Corporation has welcomed the Bioprocessing Technology Institute (BTI), a research institute under Singapore’s Agency for Science, Technology and Research (A*STAR), into its Centers of Innovation Program. BTI is the first research institute focused on glycobiology to participate in the Waters Centers of Innovation Program.

Glycans, or sugars, are one of the four fundamental classes of macromolecules that comprise living systems. BTI’s glycan research is aimed at finding novel cancer markers and elucidating glycosylation pathways that could pave the way for new therapeutic strategies.

“I am delighted that BTI has been recognized by Waters for its expertise in glycomics. Through this collaboration, BTI will be able to advance cancer biomarker research and further cement Singapore’s position as a key player in biologics,” said Lam Kong-Peng, executive director of BTI. “This award also recognizes the importance of the integrated research programmes that are fundamental to the success of BTI.”

“It’s truly a pleasure to have BTI participate in our COI Program,” said Mike Harrington, senior vice president, Global Markets for Waters Corporation. “BTI’s research in glycobiology is world-class and we wish to help it realize the enormous potential of this very important area of science through the application of Waters analytical technologies and expertise.”

In 2016, Waters and BTI announced a collaboration to develop a glycoconjugate database and spectral library that would assist researchers using mass spectrometry to identify glycans in their samples. As part of this collaboration, Waters is contributing scientific expertise and the use of a Waters SYNAPT G2-S High Definition Mass Spectrometry system. The instrument features ion mobility mass spectrometry technology that rapidly separates molecular ions by not only their size and mass-to-charge ratio, but by their shape. It also calculates a collisional cross-section (CCS) value for each molecular ion. The ability to identify glycans based on their CCS value reveals insights into their unique chemical structure that provides a higher degree of specificity than using just mass-to-charge ratio alone.

The glycoscience programme, headed by Pauline Rudd and Terry Nguyen-Khuong, will further develop and apply state-of-the-art technology to advanced bioprocessing and biologic characterization, development and production.

(Photo: (left to right) Benjamin Seet, executive director, Biomedical Research Council, A*STAR; Kong Peng Lam, executive director, BTI; Eric Fotheringham, senior director – Waters Centers of Innovation Program; and Mathieu Laouenon, general manager, South Asia, Waters Corporation.)

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