HPLC @ separationsNOW

The HPLC channel covers all techniques used for the separation of liquids.

This includes multidimensional techniques (e.g. LCxLC) and hyphenated techniques (e.g. LC-MS). Also included are capillary LC, nano LC, SEC (Size Exclusion Chromatography) and GPC (Gel Permeation Chromatography).

Gas Chromatography

Monthly Highlight

Last Month's Most Accessed Feature: Drink drug’s determination in hair described

The anti-spasticity pharmaceutical baclofen is being investigated as a possible treatment for alcoholics, but compliance with the course of treatment can be a problem. Researchers from the Raymond Poincaré and Necker Hospitals have developed a new method of measuring baclofen in the hair of treated alcoholics, using LC/MS to determine how much of the drug has been taken.

Read More thumbnail image: Last Month's Most Accessed Feature: Drink drug’s determination in hair described

2017 Free Sample Issues of Key Analytical Science Journals

The 2017 free sample issues of all our Analytical Chemistry journals are now available!

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Advertorial Feature

Journal of Separation Science Celebrates 40th Anniversary

thumbnail image: <font size=3>Journal of Separation Science Celebrates 40th Anniversary</font>

The Journal of Separation Science was born in 1978 with the name, Journal of High Resolution Chromatography, and this year celebrates its 40th birthday. To celebrate, we've created a virtual issue containing the journal's top 40 cited papers over the last four decades; and it's free for you to read for the whole of 2017.

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Micrograms enough for LC on dyestuffs

Ryan De Vooght-Johnson

Jan 16, 2018

thumbnail image: Micrograms enough for LC on dyestuffs

Various plants containing coloured alkaloids have been used as dyestuffs in the past, so there is a demand for analytical methods that can deal with small sample sizes, thus allowing the investigation of historical textiles. Scientists from Warsaw University of Technology have developed a new capillary HPLC method for these alkaloids, investigating its use with silk and wool.

LC-MS can show the way to measure hypoglycin A

Ryan De Vooght-Johnson

Jan 1, 2018

thumbnail image: LC-MS can show the way to measure hypoglycin A

Atypical myopathy is a potentially fatal horse disease caused by eating toxic plant material, such as sycamore seeds. Researchers from Jena University Hospital and the FZMB Veterinary Clinic in Bad Langensalza in Germany have developed a new UHPLC-MS/MS method to quantify the relevant toxins (hypoglycin A and MPCA-carnitine) in horse serum.

HPLC-UV and LC-MS/MS have been used to measure urinary free cortisol and cortisone and the cortisol to cortisone ratio in patients with Cushing's disease and ectopic ACTH syndrome to improve diagnostic accuracy.

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Selected key technologies of the analytical science industry are discussed by Steve Down with reference to burgeoning application areas and the scope for future improvements.

Ion source pressure plays a significant role in the process of ionization and the subsequent ion transmission inside a mass spectrometer. Pressurizing the ion source to a gas pressure greater than atmospheric pressure is a relatively new approach that aims to further improve the performance of atmospheric pressure ionization sources. A brief review on the development of super-atmospheric pressure ion sources, including high-pressure electrospray, field desorption and superheated ESI, and the strategies to...

In the current context of international conflicts and localized terrorist actions, there is unfortunately a permanent threat of attacks with unconventional warfare agents. Among these, biological agents such as toxins, microorganisms, and viruses deserve particular attention owing to their ease of production and dissemination. Mass spectrometry-based techniques for the detection and quantification of biological agents have a decisive role to play for countermeasures in a scenario of biological attacks.

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The Journal of Mass Spectrometry (JMS) publishes papers on a broad range of topics of interest to scientists working in both fundamental and applied areas involving the study of gaseous ions.

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Improving the Analysis of Polar Analytes with Novel HILIC Phases on Superficially Porous Particle LC Columns

Date: Feb 8, 2018 - 16:00

This presentation will address the use and best practices of HILIC stationary phases with regards to optimal polar compound retention. Stationary phases, solvent strength and buffers types will be addressed with respect to their unique impact on hydrophilic interaction chromatography, as well as advantages and disadvantages to the technique. Two novel HILIC chemistries on superficially porous particle columns will demonstrate these method considerations along with technical advancements in the area of...

thumbnail image: Improving the Analysis of Polar Analytes with Novel HILIC Phases on Superficially Porous Particle LC Columns
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New Thought Leader for Agilent


Nov 21, 2017

Agilent Technologies has presented its latest Thought Leader Award to Jiandong Jiang, director of the Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College in Beijing, China.

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Waters Empower Cloud

Date: Mar 8, 2017

Thomas Tucker from Waters Corporation discusses Empower Cloud, a cloud deployable, compliance ready enterprise Chromatography Data Software (CDS).

thumbnail image: Waters Empower Cloud
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