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Journal Highlight: Trypsin inhibitor from Leucaena leucocephala seeds delays and disrupts the development of Aedes aegypti, a multiple-disease vector

Date: Dec 26, 2016

Author: separationsNOW

Brazilian scientists have used gel electrophoresis to investigate a trypsin inhibitor extracted from Leucaena leucocephala seeds, which shows promise for controlling Aedes aegypti mosquitoes.

Read More thumbnail image: Journal Highlight Trypsin inhibitor from Leucaena leucocephala seeds delays and disrupts the development of Aedes aegypti a multiple-disease vector

Precision-guided payloads: Using CE to find aptamers that can target breast cancer cells

Date: Dec 19, 2016

Author: Jon Evans

Capillary electrophoresis has helped scientists in the US to come up with a novel, gentler treatment for breast cancer.

Read More thumbnail image: Precision-guided payloads Using CE to find aptamers that can target breast cancer cells

Journal Highlight: Metabolomic profiling reveals differential effects of glucagon-like peptide-1 and insulin on nutrient partitioning in ovine liver

Date: Dec 12, 2016

Author: separationsNOW

Scientists from Japan have used capillary electrophoresis and mass spectrometry to explore the role of glucagon-like peptide-1 in nutrient metabolism in sheep liver.

Read More thumbnail image: Journal Highlight Metabolomic profiling reveals differential effects of glucagon-like peptide-1 and insulin on nutrient partitioning in ovine liver

Journal Highlight: The (in)complete organelle genome: exploring the use and nonuse of available technologies for characterizing mitochondrial and plastid chromosomes

Date: Nov 28, 2016

Author: separationsNOW

In this paper, Canadian biologists argue that a range of analytical techniques, including pulsed-field gel electrophoresis and Southern and Northern blots, should be used to characterize the genomes of cellular organelles such as mitochondria and plastids.

Read More thumbnail image: Journal Highlight The incomplete organelle genome exploring the use and nonuse of available technologies for characterizing mitochondrial and plastid chromosomes

Emerging from the background: CE method for analyzing rare earth elements

Date: Nov 21, 2016

Author: Jon Evans

By optimizing the composition of the background electrolyte, Russian chemists have managed to develop a capillary electrophoresis method for separating rare earth elements.

Read More thumbnail image: Emerging from the background CE method for analyzing rare earth elements

Journal Highlight: An integrated chemical cytometry method: Shining a light on Akt activity in single cells

Date: Nov 14, 2016

Author: separationsNOW

Researchers in the US have developed an integrated analysis system that utilizes a light-programmable, cell-permeable reporter with capillary electrophoresis to study the activity of the kinase Akt in single cells.

Read More thumbnail image: Journal Highlight An integrated chemical cytometry method Shining a light on Akt activity in single cells

Journal Highlight: Multiplexed capillary electrophoresis as analytical tool for fast optimization of multi-enzyme cascade reactions – synthesis of nucleotide sugars

Date: Oct 24, 2016

Author: separationsNOW

German researchers have for the first time demonstrated the use of multiplexed capillary electrophoresis as a fast analytical tool for the optimization of nucleotide sugar synthesis with multi-enzyme cascade reactions.

Read More thumbnail image: Journal Highlight Multiplexed capillary electrophoresis as analytical tool for fast optimization of multi-enzyme cascade reactions  synthesis of nucleotide sugars

A blot on the beads: Western blotting with a bead-based immunoassay

Date: Oct 18, 2016

Author: Jon Evans

By combining Western blotting with a bead-based immunoassay, German scientists have developed a novel proteomics technique that can conduct 200 separate analyses using the same amount of sample as required for a single conventional Western blot.

Read More thumbnail image: A blot on the beads Western blotting with a bead-based immunoassay

Journal Highlight: Possibilities and limitations of 2DE-based analyses for identifying low-abundant tumor markers in human serum and plasma

Date: Oct 10, 2016

Author: separationsNOW

This review explores the use of 2D gel electrophoresis to discover cancer biomarkers in serum/plasma and also proposes an optimized experimental workflow for detecting cancer-specific protein markers of low abundance.

Read More thumbnail image: Journal Highlight Possibilities and limitations of 2DE-based analyses for identifying low-abundant tumor markers in human serum and plasma

Journal Highlight: Differential protein expression in the midgut of Culex quinquefasciatus mosquitoes induced by the insecticide temephos

Date: Sep 26, 2016

Author: separationsNOW

Scientists in Brazil and the US used 2D gel electrophoresis to investigate the effect of the insecticide temephos on the expression of midgut proteins in a mosquito.

Read More thumbnail image: Journal Highlight Differential protein expression in the midgut of Culex quinquefasciatus mosquitoes induced by the insecticide temephos
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