Charge variant analysis for throughput process development

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  • Date: Mar 26, 2013 - 16:00 - 17:00 (local time)
  • Presenter: Dr Simon Briggs, Senior Scientist, In-Process Analytics Team
  • Categories: HPLC
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Charge variant analysis for high throughput process development

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Broadcast on March 26, 2013

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Process development requires suitable analytical methods which are able to demonstrate process robustness for both upstream or downstream processes. The use of QbD and the increasing numbers of samples which require analysis has meant that we have had to employ new and higher throughput technologies in order to cope. One of the most troublesome assays to perform is charge variant analysis by CEX-HPLC which has been notoriously time consuming to perform and lacks the robustness required for high throughput applications.

Utilizing the iCE3 with an Alcott autosampler we have been able to utilize the high throughput sampling of the device and be assured that the system delivers well controlled and reliable results. We will demonstrate comparability and robustness of the technique applied to analysis of process development samples.

What You Will Learn About:

  • Rapid charge heterogeneity analysis of biopharmaceuticals
  • Reducing method development time while increasing peak resolution
  • Implementation of high throughput charge heterogeneity methods for upstream and downstream process development

Who Should Attend:

  • QC Laboratory Managers
  • R&D Scientists
  • Scientists performing Charge Heterogeneity Analysis
  • Process Development Scientists/Managers
  • Scientist using Capillary Electrophoresis or HPLC
  • Scientists using Gel Isoelectric Focusing
  • CMO/CRO Scientist and Managers
  • Formulation Chemists/Scientists
  • Protein Analytical Development Scientists
  • Routine testing groups

Your Presenter

Dr. Simon Briggs

Senior Scientist, In-Process Analytics Team
UCB Pharma


Simon Briggs obtained his degree in Biotechnology and Chemistry at the University of Plymouth (UK) followed by completion of his PhD at the University of Birmingham (UK) in 2004 in the field of polymers and gene therapy. Following his PhD Simon spent a number of years at the University of Oxford (UK) where he continued his research into the use of polymeric materials and controlled polymer synthesis on biological surfaces for gene therapy. This work also fuelled an interest into purification and analytical techniques especially relating to GMP manufacturing of these new products. Since then, Simon has been with UCB Pharma, based in Slough, UK, in the In-Process Analytics Team as a senior scientist, working on projects in both early phase development and later stage commercialization type activities.

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