Increased Selectivity, Analytical Precision, and Throughput in Targeted Proteomics

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Webinar

  • Date: Oct 12, 2010 - 15:00 - 16:00 (local time)
  • Presenter: Enter an Author name
  • Categories: Proteomics & Genomics / Proteomics
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Increased Selectivity, Analytical Precision
and Throughput in Targeted Proteomics


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Proteomics is gradually complementing large shotgun qualitative studies with hypothesis-driven quantitative experiments.

Targeted analyses performed on triple quadrupole instruments in selected reaction monitoring (SRM) mode are characterized by a high degree of selectivity and low limit of detection; however the concurrent analysis of multiple analytes occurs at the expense of sensitivity due to reduced dwell time and/or selectivity due to limitation to a few transitions.

Professor Domon, along with collaborators at Thermo Fisher Scientific, have developed a new data acquisition paradigm, called intelligent SRM (iSRM), in which data acquisition is optimized and SRM is performed to simultaneously quantify and confirm the identity of the targeted peptides.

In this presentation, Professor Domon describes the concept of iSRM and the workflow associated with it. In addition, he demonstrates the increased throughput as a result of iSRM implementation, facilitating the development of SRM assays, and its ability to perform large-scale screens targeting a respectable number of proteins.


Your speaker:

Bruno Domon Professor Bruno Domon
Director of the Luxembourg Clinical Proteomics Center (LCP) of the CRP-Santé, Luxembourg

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