New Tribrid Mass Spectrometer Delivers New Levels of Power and Performance for Protein and Small Molecule Characterization

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  • Published: Jun 5, 2017
  • Source: Thermo Fisher Scientific
  • Channels: Proteomics & Genomics / HPLC / Proteomics / Base Peak
thumbnail image: New Tribrid Mass Spectrometer Delivers New Levels of Power and Performance for Protein and Small Molecule Characterization

Thermo Scientific Orbitrap Fusion Lumos Tribrid mass spectrometer features integrated UVPD, advanced peak determination and 1M resolution

INDIANAPOLIS, ASMS 2017. June 5, 2017.

Scientists facing highly complex characterization challenges can now gain a deeper understanding of their samples with new enhancements to the industry-leading Thermo Scientific Orbitrap Fusion Lumos Tribrid mass spectrometer that extend its power, performance and versatility.

“When we launched the Orbitrap Fusion Lumos Tribrid mass spectrometer at ASMS two years ago, we redefined protein and small molecule quantitation and characterization, and this year, we pushed these limits even further,” said Ken Miller, vice president, omics marketing, chromatography and mass spectrometry, Thermo Fisher. “The ability to intelligently select the most promising precursor ions, create new sequence- or structure-informative fragments, and characterize them to the level of fine isotope structure is a constellation of new capabilities that make the Fusion Lumos mass spectrometer essential for the most advanced proteomics, metabolomics and small molecule research discoveries.”

The Orbitrap Fusion Lumos instrument brings an unprecedented level of structural information for improved identification and characterization to scientists performing top down proteomics, small molecule characterization, lipidomics and biopharma research. New enhancements include:

  • Integrated Ultraviolet Photodissociation (UVPD) that allows researchers to perform large and small molecule structure determination on an LC time scale. Now an optional feature on Orbitrap Fusion Lumos systems, this unique fragmentation mode is designed to improve sequence coverage and antibody characterization, decreases scrambling in top-down hydrogen deuterium exchange (HDX) experiments and created to be a complete solution for structural characterization of lipids and other metabolites. This provides researchers with more complete structural information to solve their complex structure assignment challenges. The enhancement is supported by the new Thermo Scientific Xcalibur 4.1 software, an easy-to-use, flexible and efficient solution that is intended to enable simple method setup, data acquisition, processing and reporting through an intuitive interface.
  • New Advanced Peak Determination (APD) algorithm that is designed to improve performance of most proteomic workflows with high peptide and protein identification rates in data-dependent experiments.
  • 1M resolution, which is now available for researchers who need ultra-high resolution to confidently measure fine isotope structures or separate isobaric compounds. This new option, used to obtain unique structural and quantitative information for a wide range of compound classes, aids scientists in proteomics, pharmaceutical, metabolomics, fluxomics and industrial chemical applications

Thermo Fisher is featuring the Fusion Lumos Tribrid mass spectrometer during the 65th Annual American Society for Mass Spectrometry (ASMS) Conference, being held June 4-8, in the White River Ballroom F-J at the JW Marriott, Indianapolis. For more information, visit

About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. is the world leader in serving science, with revenues of $18 billion and more than 55,000 employees globally. Our mission is to enable our customers to make the world healthier, cleaner and safer. We help our customers accelerate life sciences research, solve complex analytical challenges, improve patient diagnostics and increase laboratory productivity. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services – we offer an unmatched combination of innovative technologies, purchasing convenience and comprehensive support. For more information, please visit

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