Waters unveils new microscale LC device

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  • Published: Aug 19, 2016
  • Author: Jon Evans
  • Source: Waters
  • Suppliers: Waters Corporation
  • Channels: HPLC
thumbnail image: Waters unveils new microscale LC device

Waters Corporation will unveil a new line of chromatographic fittings and a new microscale separations device at the 21st International Mass Spectrometry Conference, taking place in Toronto, Canada, on 20–26 August 2016. The new products allow research scientists doing nano-to-microscale liquid chromatography (LC) to achieve greater levels of productivity for peptide bioanalyses and for pharmacokinetic and endogenous peptide biomarker validation studies.

The Waters 300µm i.d. microfluidic device, the iKeyTM HT, is a new addition to the company’s ionKey/MSTM microscale chromatography product portfolio. The iKey HT device is a ceramic tile that is etched with a 300µm i.d. channel packed with 1.7µm or 1.8µm UPLC particles, which takes the place of a traditional capillary column. The larger i.d. microchannel etched into the new device allows scientists to run separations at higher flow rates as compared to the 150µm i.d. tile. This shortens run times to three minutes or less, comparable to the run time of a conventional LC separation performed on a 2.1mm i.d. column.

A new white paper from Waters details a study in which 1000 injections of a crashed plasma sample containing six small molecule analytes were run on the same prototype BEH C18 iKey HT device (300µm x 50mm, 1.7µm). The results showed a coefficient of variation (% CV) of less than 5%, at least a two times gain in sensitivity over UPLC/UHPLC, and a cycle time of less than three minutes for each sample run.

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