Journal Highlight: Trimethylamine N‐oxide as a risk marker for ischemic stroke in patients with atrial fibrillation

Trimethylamine N‐oxide as a risk marker for ischemic stroke in patients with atrial fibrillation

Journal of Biochemical and Molecular Toxicology, 2018, e22246 online
Zhaoguang Liang, Zengxiang Dong, Meihua Guo, Zhaoqian Shen, Dechun Yin, Shuang Hu, Xin Hai

Abstract: Trimethylamine N‐oxide (TMAO) is an independent risk factor of cardiovascular disease. Our objective was to explore the relation between TMAO and ischemic stroke (IS) in patients with atrial fibrillation (AF). A total of 68 patients with AF with IS and 111 ones without IS were enrolled. The plasma levels of TMAO remarkably increased in IS‐AF patients (8.25 ± 1.58 µM) compared with patients with AF (2.22 ± 0.09 µM, P < 0.01). The receiver operating characteristic analysis revealed that the best cutoff value of TMAO to predict IS in patients with AF was 3.53 µM with 75.0% sensitivity and 92.8% specificity (area under the curve: 0.917, 95% confidence intervals: 0.877‐0.957). Univariate and multivariate logistic regression analysis showed that TMAO was an independent predictor in IS. The level of TMAO was correlated with the CHA2DS2‐VASc score. In conclusion, TMAO was an independent predictor of IS, which could potentially refine stroke stratification in patients with AF.

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