Strategies and Challenges in Identifying Function for Thousands of sORF‐Encoded Peptides in Meiosis

Skip to Navigation

EarlyView Article

  • Published: Oct 26, 2017
  • Author: Ina Hollerer, Andrea Higdon, Gloria A. Brar
  • Journal: PROTEOMICS

Abstract

Recent genomic analyses have revealed pervasive translation from formerly unrecognized short open reading frames (sORFs) during yeast meiosis. Despite their short length, which has caused these regions to be systematically overlooked by traditional gene annotation approaches, meiotic sORFs share many features with classical genes, implying the potential for similar types of cellular functions. We found that sORF expression accounts for approximately 10–20% of the cellular translation capacity in yeast during meiotic differentiation and occurs within well‐defined time windows, suggesting the production of relatively abundant peptides with stage‐specific meiotic roles from these regions. Here, we provide arguments supporting this hypothesis and discuss sORF similarities and differences, as a group, to traditional protein coding regions, as well as challenges in defining their specific functions.

Social Links

Share This Links

Bookmark and Share

Microsites

Suppliers Selection
Societies Selection

Banner Ad

Click here to see
all job opportunities

Most Viewed

Copyright Information

Interested in spectroscopy? Visit our sister site spectroscopyNOW.com

Copyright © 2017 John Wiley & Sons, Inc. All Rights Reserved