# Evaluation of the quality consistency of powdered poppy capsule extractive by an averagely linear‐quantified fingerprint method in combination with antioxidant activities and two compounds analyses

## EarlyView Article

• Published: Oct 27, 2017
• Author: Yujing Zhang, Guoxiang Sun, Zhifei Hou, Bo Yan, Jing Zhang
• Journal: Journal of Separation Science

### Abstract

A novel averagely linear‐quantified fingerprint method was proposed and successfully applied to monitor the quality consistency of alkaloids in powdered poppy capsule extractive. Averagely linear‐quantified fingerprint method provided accurate qualitative and quantitative similarities for chromatographic fingerprints of Chinese herbal medicines. The stability and operability of the averagely linear‐quantified fingerprint method were verified by the parameter r. The average linear qualitative similarity ${S}_{L}$ (improved based on conventional qualitative “Similarity”) was used as a qualitative criterion in the averagely linear‐quantified fingerprint method, and the average linear quantitative similarity ${P}_{L}$ was introduced as a quantitative one. ${P}_{L}$ was able to identify the difference in the content of all the chemical components. In addition, ${P}_{L}$ was found to be highly correlated to the contents of two alkaloid compounds (morphine and codeine). A simple flow injection analysis was developed for the determination of antioxidant capacity in Chinese Herbal Medicines, which was based on the scavenging of 2,2‐diphenyl‐1‐picrylhydrazyl radical by antioxidants. The fingerprint–efficacy relationship linking chromatographic fingerprints and antioxidant activities was investigated utilizing orthogonal projection to latent structures method, which provided important pharmacodynamic information for Chinese herbal medicines quality control. In summary, quantitative fingerprinting based on averagely linear‐quantified fingerprint method can be applied for monitoring the quality consistency of Chinese herbal medicines, and the constructed orthogonal projection to latent structures model is particularly suitable for investigating the fingerprint–efficacy relationship.

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