Elimination profile of triamcinolone in urine following oral administration

Skip to Navigation

EarlyView Article

  • Published: Dec 11, 2017
  • Author: Ting‐Ting Chen, Yi‐Chun Tseng, Tai‐Yuan Huang, Guo‐Ping Chang‐Chien, Mei‐Chich Hsu
  • Journal: Drug Testing and Analysis


Triamcinolone (T) is a glucocorticoid commonly used to relieve inflammation and treat arthritis, severe allergies, and asthma; however, it is banned by the World Anti‐Doping Agency in competition for athletes when administered orally, intravenously, intramuscularly, or rectally. The minimum required performance limit (MRPL) for urinary T is 30 ng/mL. However, the data about the urinary excretion of T after oral administration is limited. We investigate the elimination profile and determine whether single‐dose administration of T would cause a positive doping result. Twelve healthy volunteers received a single‐dose of 4‐mg T rally, and urine samples were collected for 24 hours. A validated liquid chromatography–tandem mass spectrometry method was used to determine urinary T levels. Non‐compartmental modeling was used to estimate the pharmacokinetic parameters. All the urinary T concentrations were much higher than the MRPL. The peak urinary T concentration was 3211.4 ± 860.3 ng/mL (mean ± SD), time to peak concentration was 1.7 ± 0.9 hours, and the estimated elimination half‐life was 4.4 ± 2.8 hours. About 27.76% of the consumed dose was eliminated via urine within 24 hours of intake. After a single‐dose oral administration, urinary T concentrations still exceeded the MRPL after 24 hours. This information could be useful for limiting the misuse of T. Athletes should be aware when using T in competition and acquire approval for a therapeutic use exemption prior to use. Moreover, the elimination profile of orally administered T may be crucial information for distinguishing different dosage routes.

Social Links

Share This Links

Bookmark and Share


Suppliers Selection
Societies Selection

Banner Ad

Click here to see
all job opportunities

Most Viewed

Copyright Information

Interested in spectroscopy? Visit our sister site spectroscopyNOW.com

Copyright © 2018 John Wiley & Sons, Inc. All Rights Reserved