AB SCIEX in antibody analysis agreement

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  • Published: Aug 30, 2014
  • Author: Jon Evans
  • Suppliers: AB SCIEX
  • Channels: Electrophoresis / Laboratory Informatics / HPLC / Proteomics & Genomics / Sample Preparation / Ion Chromatography / Gas Chromatography / Detectors

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AB SCIEX has agreed to enter into a research collaboration with Dalton Pharma Services, a Canadian contract manufacturer to the biotechnology and pharmaceutical industries, for the development of antibody-drug conjugate (ADC) analysis capabilities.

This will involve Dalton scientists preparing ADCs and then working with AB SCIEX to develop analytical procedures for characterizing them, including identifying drug loading and the position of conjungation on macromolecules. These analytical procedures will be based on liquid chromatography-mass spectrometry (LC-MS) and will utilize AB SCIEX's TripleTOF MS instruments.

'Recent advances in mass spectrometry have provided a solution to answer the challenging questions in terms of understanding ADC drug development and working within a biological matrix,' said Chris Radloff, vice president, LC/ MS business, at AB SCIEX. 'Utilizing these molecules is difficult and by forming this partnership, ADC developers can now reduce complications, and obtain accurate results that will ultimately lead to safer, more effective therapies.'

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