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Ion Chromatography Ezine
Wake up and smell the coffee Wake up and smell the coffee 
By probing the properties of a little-known family of flavour compounds in coffee, Dutch food chemists have come up with an anion exchange chromatography-based method for isolating them for more detailed study. [June 9, 2008]

High-throughput screening of chromatographic separations: I. Method development and column modeling High-throughput screening of chromatographic separations: I. Method development and column modeling  [registered users only]
US pharmaceutical scientists have developed a high-throughput screening method to optimise chromatography processes for purifying proteins, which they used to optimise an anion-exchange purification process. [June 2, 2008]

Improved recovery of protein N-terminal peptides by combined fractional diagonal chromatography Improved recovery of protein N-terminal peptides by combined fractional diagonal chromatography  [registered users only]
Belgian researchers have shown that the sensitivity of a new chromatography technique known as combined fractional diagonal chromatography can be enhanced by adding a strong cation exchange step. [May 26, 2008]

IC reaches DNA base camp IC reaches DNA base camp 
Ion chromatography could challenge high performance liquid chromatography and capillary electrophoresis as the most effective technique for separating DNA bases, say a team of Chinese and Belgian scientists. [May 12, 2008]

Large-scale phosphoproteome analysis of human liver tissue with strong anion exchange chromatography Large-scale phosphoproteome analysis of human liver tissue with strong anion exchange chromatography  [registered users only]
Chinese researchers have shown that cation exchange chromatography is an effective means for enriching and fractionating phosphopeptides, allowing them to identify over 300 unique phosphopeptides in samples of human liver tissue. [May 5, 2008]

Two-dimensional strong cation exchange/porous layer open tubular/mass spectrometry for ultratrace proteomic analysis Two-dimensional strong cation exchange/porous layer open tubular/mass spectrometry for ultratrace proteomic analysis  [registered users only]
US chemists have developed a new technique for ultratrace proteomic analysis, which involves incorporating on-line sample desalting using a triphasic trapping column connected to a porous layer open tubular column. [April 28, 2008]

There will be blood There will be blood 
Bringing artificial blood a step closer to the operating table, two US biomolecular engineers have developed a simple anion exchange chromatography method for obtaining pure haemoglobin from human and cow red blood cells. [April 14, 2008]

Improved ancient DNA purification for PCR using ion-exchange columns Improved ancient DNA purification for PCR using ion-exchange columns  [registered users only]
Asian scientists have developed a novel method of ancient DNA purification using ion-exchange columns to improve PCR-amplifiable DNA extraction from ancient bone samples. [April 7, 2008]

Separation of cytidine triphosphate from fermentation broth of yeast using anion-exchange cryogel Separation of cytidine triphosphate from fermentation broth of yeast using anion-exchange cryogel  [registered users only]
Chinese scientists have developed a novel separation method to isolate directly cytidine triphosphate from yeast fermentation broth using an anion-exchange supermacroporous cryogel. [March 24, 2008]

Ditching sodium and fixing nitrogen Ditching sodium and fixing nitrogen 
Anion exchange chromatography doesn't tend to work well with mass spectrometry, but by finding a way around this problem French chemists have come up with a novel system for identifying cell surface polysaccharides. [March 10, 2008]

Evaluation of separation in gradient elution IC by combining several retention models and objective functions Evaluation of separation in gradient elution IC by combining several retention models and objective functions  [registered users only]
By combining three different gradient retention models and several optimization objective functions, Croation scientists have discovered an efficient technique for optimising ion chromatography methods. [March 3, 2008]

Improving the resolution of neuropeptides with on-line HILIC-RP compared to on-line SCX-RP Improving the resolution of neuropeptides with on-line HILIC-RP compared to on-line SCX-RP  [registered users only]
European scientists have compared two 2D LC systems - strong cation exchange-RP and hydrophilic interaction LC-RP - to determine which is best for studying cerebral neuropeptide expression as a function of hypoxia-caused stress. [February 25, 2008]

Dosing up on selenium Dosing up on selenium 
Two Taiwanese chemists have come up with a quick and easy way to determine the concentration of selenium in food products such as flour, by combining inductively coupled plasma mass spectrometry with ion chromatography. [February 11, 2008]

Purification of an acidic recombinant protein from transgenic tobacco Purification of an acidic recombinant protein from transgenic tobacco  [registered users only]
US biological scientists have developed a new process for purifying a model acidic protein from transgenic tobacco based on polyelectrolyte precipitation, hydrophobic interaction chromatography and hydroxyapatite chromatography. [February 4, 2008]

Study on the retention behavior of aromatic carboxylic and sulfonic acid on a new anion exchange column Study on the retention behavior of aromatic carboxylic and sulfonic acid on a new anion exchange column  [registered users only]
Chinese environmental chemists have assessed the retention beahviour of aromatic anions on a novel anion exchange chromatography column developed using a unique polymer bonding technology. [January 28, 2008]

Picking armchairs from zigzags Picking armchairs from zigzags 
Nanotechnology researchers have always struggled to produce single-walled carbon nanotubes with defined electrical properties, but a solution might now be forthcoming thanks to ion exchange chromatography. [January 14, 2008]

Chromatographic NMR: a tool for the analysis of mixtures of small molecules Chromatographic NMR: a tool for the analysis of mixtures of small molecules  [registered users only]
In this review paper taken from the recent published Special issue of MRC dedicated to new techniques in solid-state NMR, the author covers some of the principles and the practicality of using the high-resolution magic angle spinning - pulsed field gradient (HRMAS-PFG) approach for the study of mixtures. [January 10, 2008]

Development of a two-step chromatography procedure for purifying an immunosuppressant antibody Development of a two-step chromatography procedure for purifying an immunosuppressant antibody  [registered users only]
Japanese and Taiwanese researchers have developed an anion-exchange chromatography procedure for purifying a novel anti-histone monoclonal antibody with immunosuppressant activity, which could find use in organ transplants. [January 7, 2008]

Comparison of nonporous silica-based ion exchangers and monolithic ion exchangers Comparison of nonporous silica-based ion exchangers and monolithic ion exchangers  [registered users only]
Russian scientists have prepared low capacity anion exchangers for ion chromatography by modifying nonporous uniformed silica microbeads and the organic polymeric monolithic matrixes in a quartz capillary. [December 24, 2007]

IEC cream IEC cream 
By designing a stationary phase with a similar structure to ice cream, Chinese chemists have developed a novel ion-exchange chromatography process for isolating the cellular fuel molecule adenosine triphosphate. [December 10, 2007]

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